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Hypersensitivity to barbiturates or any element of the formulation; ; record of manifest or latent porphyriabutabarbital will lower the level or influence of levamlodipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism.butabarbital will reduce the level or result of levoketoconazole by influencing hepatic/intestinal enzyme CYP3A4 metabo